Decision support (coming soon)

Differential diagnosis

Model: aug-differential · Status: Coming soon · Scope: agents:differential · Schema: differential/0.1

Ranks possible diagnoses for a presentation, separates must-not-miss conditions, explains what supports and argues against each, and proposes the tests that best discriminate between them.

Request

JSON

{
  "model": "aug-differential",
  "messages": [{"role": "user", "content": "34F, 6 weeks low mood, anhedonia, early waking, 3 kg weight loss, poor concentration, guilt, passive death wishes. TSH 2.1."}],
  "augsidius": {"audience": "clinician", "instructions": {"max_items": 8}}
}

Response payload

JSON

{
  "resolved_context": {"observations": [{"text": "anhedonia", "concept_id": "…", "present": true}]},
  "differential": [
    {"concept_id": "…", "name": "Major depressive disorder", "band": "likely",
     "for": ["Depressed mood", "Anhedonia", "Early morning awakening", "Weight loss"],
     "against": [], "must_not_miss": false,
     "next_tests": [{"name": "PHQ-9", "kind": "calculator"}, {"name": "Columbia Suicide Severity Rating Scale", "kind": "calculator"}]},
    {"concept_id": "…", "name": "Bipolar depression", "band": "possible",
     "for": ["Depressed mood"], "against": ["No past mania reported"], "must_not_miss": false,
     "next_tests": [{"name": "Mood Disorder Questionnaire", "kind": "calculator"}]}
  ],
  "must_not_miss": [{"name": "Suicide risk", "why": "Passive death wishes reported", "action": "Assess intent, plan and means today"}],
  "unresolved": []
}

band is one of likely, possible, less likely. Bands reflect fit with the observations and real-world frequency (including Indian prevalence where available); they are not calibrated probabilities.

Tip: for an interactive work-up, use care-model sessions instead — the differential updates as you add each finding.

Evidence cards

Medication safety